International Journal of Fauna and Biological Studies
2014, Vol. 1 Issue 5, Part B
Effects of fluoride exposure on some enzymatic and histopathological changes in the liver of Heteropneustes fossilis (Bloch).
Shiv Shankar Yadav, Rajesh Kumar, Madhu Tripathi
Present study in fresh water fish Heteropneustes fossilis
(Bloch) were exposed to sub lethal concentrations (35 mg/L and 70 mg/L) of fluoride, for 45 days & 90 days. After fluoride exposure aspartate transaminase (AST) and alanine transaminase (ALT) increased (P <0.01) after 45 & 90 days of low and high dose exposure. There were decreases of protein P > 0.05 after 90 days exposure to both low and high dose exposure. After 45days exposure p<0.01 decreases high concentration of fluoride. The lipid accumulation could have contributed to the increase of liver weight. After 45 & 90 daysâ€™ exposure of fluoride histopathological observations of liver at low & high dose concentration. As a result foci of necrosis fibrosis, pyknotic nuclei, disruptions and rupture as well as hypertrophy & hyperplasia of hepatocytes were found. The changes included swollen cells, vacuoles filled with cellular debris, focal necrosis, and dilatation of sinusoids.
Control Low dose Fluoride exposure High dose Fluoride exposure
Pages: 80-84 | 1644 Views 174 Downloads
Shiv Shankar Yadav, Rajesh Kumar, Madhu Tripathi. Effects of fluoride exposure on some enzymatic and histopathological changes in the liver of Heteropneustes fossilis (Bloch).. Int. J. Fauna Biol. Stud. 2014;1(5):80-84.