Author(s):

Dr. Shikha Sharma, Dr. Pragya Singh, Dr. MK Aggarwal

Abstract: Lead is a ubiquitous environmental pollutants, known to impede the reproductive function. However, mechanism through the adverse effects are mediated, has not been clearly elucidated. In order to get insight into the mechanism, the effect of lead on fertility impairment in female rats via hypothalamus-pituitary-ovarian axis were examined. Chronic exposure to lead (5mg/kg body weight of lead acetate was given subcutaneously every second day from the age of 16 days until the age of 71days), FSH and estradiol-17 B level of blood while LH and progesterone level revealed variable effects. Degranulation and degeneration of few gonadotrophs of pituitary, reversible ovarian vascular damage with haemorrhages, follicular degeneration and necrosis, suppressed puberty growth rates, delayed vaginal opening and disrupted estrus cycling were other adverse effects induced by chronic lead exposure.

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