AK Vishwakarma and Pradeep Kumar

Fascioliasis is a serious disease that damages the livers of cattle, which lowers livestock productivity. These trematodes are responsible for food-borne zoonotic infections, which impact widespread public health. This causes a lot of financial problems to people. By removing the sporocyst, redia, and cercaria larvae of Fasciola gigantica, the parasite's life cycle can be broken and fascioliasis can be control in human populations. The goal of the present study was to determine how well dried root powder (DRP), various organic extracts, and column-purified A. racemosus worked as anthelmintic larvicides against F. gigantica sporocyst, redia, and cercaria larvae. DRP, various organic extracts, and column-purified A. racemosus were exposed in vitro to sporocyst, redia, and cercaria larvae for up to 8 hours at varying concentrations. Larval mortality was noted after two, four, six, and eight hours of treatment. A. racemosus DRP was more effective against cercaria larvae (2h LC₅₀ 60.22 mg/l and 8h LC₅₀ 51.66 mg/l). For sporocyst, redia, and cercaria, the ethanol extract's 8h LC₅₀ was 40.43, 37.22, and 38.74 mg/l, respectively. Ethanol extract outperformed the other organic extracts in terms of effectiveness.

The column purified fraction of A. racemosus had an 8h LC₅₀ of 38.25, 34.31, and 34.63 mg/l against cercaria, redia, and sporocyst, respectively.

DOI: 10.22271/23940522.2025.v12.i2b.1090

Pages: 102-106  |  60 Views  25 Downloads