Ujjwala Shivaji Deshmukh and Sharvari Shivaji Deshmukh

Alstonia scholaris, a plant known for its medicinal properties, was investigated for its antibacterial activity against Staphylococcus aureus using leaf extracts prepared in methanol, acetone, ethanol, chloroform and distilled water. The antibacterial potential of each extract was evaluated in vitro through the agar well diffusion method. After 24 hours of incubation at 37 ± 1 °C, zones of inhibition were recorded, with the aqueous extract showing the highest activity (15 mm), followed by methanolic (14 mm), acetonic (13 mm), ethanolic (10 mm) and chloroform (6 mm) extracts. These results were compared to the inhibition zones produced by standard antibiotics Vancomycin Hydrochloride (28 mm) and Maczone (20 mm). Although the plant extracts demonstrated comparatively lower antibacterial activity than the commercial antibiotics, the aqueous and methanolic extracts exhibited notable inhibitory effects, indicating the presence of bioactive constituents. These findings warrant further phytochemical and mechanistic studies to explore the therapeutic potential of Alstonia scholaris as a source of novel antibacterial agents.

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