Author(s): Shiv Shankar Yadav, Rajesh Kumar, Madhu Tripathi

Abstract: Present study in fresh water fish Heteropneustes fossilis (Bloch) were exposed to sub lethal concentrations (35 mg/L and 70 mg/L) of fluoride, for 45 days & 90 days. After fluoride exposure aspartate transaminase (AST) and alanine transaminase (ALT) increased (P <0.01) after 45 & 90 days of low and high dose exposure. There were decreases of protein P > 0.05 after 90 days exposure to both low and high dose exposure. After 45days exposure p<0.01 decreases high concentration of fluoride. The lipid accumulation could have contributed to the increase of liver weight. After 45 & 90 days’ exposure of fluoride histopathological observations of liver at low & high dose concentration. As a result foci of necrosis fibrosis, pyknotic nuclei, disruptions and rupture as well as hypertrophy & hyperplasia of hepatocytes were found. The changes included swollen cells, vacuoles filled with cellular debris, focal necrosis, and dilatation of sinusoids.